yes
While the zone syncing is good enough for multiple rooms, it’s not good enough to do sync between channels. You will probably get drift and this will not sound right.
You will need to run a cable or use a speaker/sub setup that supports wireless sync that is meant for this.
I know @mitr is familiar with this, but for everyone else, this concept is basically making Roon be the crossover by using Roon’s DSP and channel routing.
This requires a multichannel sound device to pull off, but the flexibility and control you get in this approach is awesome.