Roon Version: 1.3 (build 247) stable (64bit)
OS: Windows 10 Pro - Version 1703 - OS Build 15063.502
PC spec: i7 6850k, 32gb ddr4, GTX 1080
Library Size: 31,797 tracks
DAC - Chord Mojo (Driver Version 188.8.131.52)
The issue appears very similar to one I had in April this year. With Roon open and in use I clicked next on a song and the audio devices disappeared.
After restarting Roon the audio devices appear for a few seconds then disappear again.
No windows updates occurred today before the issue started with the most recent being my current build https://support.microsoft.com/en-us/help/4032188/windows-10-update-kb4032188 which was installed a few days ago.
I do not have a system restore point before the Windows update but it would be odd for that to be impacting Roon now after working for days.
Troubleshooting steps tried so far:
Uninstall/ Reinstall of Roon with and without restoring a backup.
Uninstall/ Reinstall of latest Chord drivers
Uninstall/ Reinstall of latest Nvidia graphics drivers
System / Chord Mojo power on/off
Swapped between several USB ports.