I have a 2-story house and had a very difficult time with streaming in extreme ends, until I got the EERO mesh networking system. Now, the entire family can stream high-res music, video, etc. at the same time without any issues throughout the house.
I also have a stereo-paired HomePods that work great. Though Roon doesn’t support AirPlay 2, someone found an interesting workaround that I am using and having great success with it.