I have a Core system in my mastering studio upstairs, connected to a NAS and it works great. I have a computer in the basement studio running as a Roon remote that can find the upstairs Core and upstairs connected audio, but doesn’t show the local downstairs audio interface. (Both upstairs and downstairs have Focusrite converters).
I can connect to both computers from each other, and even run remote desktop at good speed.
Upstairs and downstairs are connected via a Buffalo WiFi to ethernet port. They both have smooth internet access.