Moon 280D usb connection with nucleus problem

MOON’s MQA implementation only works using the network (MiND v2) input on the device. There is no other MQA support on any other input (including USB).

Why not use the network input instead of USB? It’s Roon Ready and supports all of the same formats as USB. Plus it gives you the benefit of tighter integration and using the DAC’s remote to operate the transport controls (play / pause, skip, etc).