Yes. In fact Roon can do the first MQA unfold, apply DSP (except upsampling, which messes with MQA) and retain the MQA rendering information for an MQA Renderer.
I like to use the first MQA unfold in Roon and then send the 88.1/96 kHz signal to HQP where I do room convolution, upsample to DSD 512 and then send the whole sorry mess to a NOS R2R DAC (Holo Audio Spring).
If you’d told me 4 years ago that I’d be doing that to an audio signal I would have laughed at you. But I like the way it sounds.