Technical quality of -2s filters is practically equivalent of non-2s. But they are not mathematically exactly same, so there are some small objective differences which may lead to some subjective differences too. Second stage of 2s filters is one specifically designed for that purpose, relying on the earlier filter stage. First stage is always at least 8x, so the total ratio needs to be 16x or more, otherwise the filter operates just like the non-2s (without second stage).
Whether there is audible difference between the two variants depends, but it should be very small anyway. But from technical quality perspective one doesn’t need to worry.