Roon locks up on startup Mac OS Monterey 12.0.1

If there’s no specific reason you haven’t updated to Monterey 12.1 I’d start there. Also, when you say you’ve removed the app and reinstalled, did you also delete ~/Library/Roon ? If not, try renaming that folder (e.g. Roon_old) as that will remove your previous settings for the app. If that works you can delete ‘Roon_old’. If not, to return you back to where you started, delete the new ~/Library/Roon folder and rename ‘Roon_old’ back to ‘Roon’.