For anyone using a MOTU DAC. I was having problems with Roon losing control of the device. I initially thought using the WASAPI driver solved the problem. It didn’t.
The issue occurred when Roon played a track at a different sample rate than the MOTU was set to. Once I set the motu to 96kHz, and had Roon convert all files to a sample rate of 96kHz, the problem went away.