I don’t know the Mytek products but probably not as Roon usually supports only one zone per output device or more precisely way of playback like e.g,: RoonReady, ChromeCast, AirPlay, … You can use DSP Presets (top left in DSP screen) to store the different setups of Roon’s DSP engine for your two use cases and quickly switch between them (works even when Roon is controlled from a phone). A quick look at the signal path when you start a listening session can tell you if your setup is correct or not.