Current Roon setup involves:

Core running on i7-6700k quad-core Win10 Desktop. Samsung 850 250 GB EVO SSD. 16 GB (2x8GB) DDR4 Corsair Vengeance LPX Ram. NVidia GTX 1060 (6 GB) GPU. Multi-purpose Roon + Plex + Steam server.

Files stored on QNAP TS-431+ NAS, also running HDHomeRun DVR.

Network run by TP-Link Archer AX6000. Ethernet run through the walls and used/preferred over wireless whenever possible.

Main Speaker (Living Room) System:
OPPO UDP-203 --> Denon x4400h --> Ascend Sierra Towers (w/RAAL) and Rythmik F25 sealed servo sub.
Chromecast Audio secondary endpoint for whole-home.

Main headphone (Sunroom) system:
Raspberry Pi 4B running RoPieeee --> Schiit Jotunheim DAC/Amp --> Audeze LCD-2C or Sennheiser HD-6XX.

Secondary (whole-home-audio) setups
Basement
Onkyo TX-NR809 --> Polk Monitor 70 Series II & SVS PB-1000
Via Raspberry Pi RoPieee SPDIF out (for grouping with living room OPPO)
Via Chromecast Audio (for grouping with whole-home)

Loft
Pioneer VSX-521-K --> JBL Studio 530 via CCA

Bedroom
Onkyo TX-SR606 --> Emp Tek R5Bi via CCA

Patio
Klipsch R-15PM via CCA

Workout Room
Zone 2 of Onkyo TX-NR809 --> Polk Monitor 35B

Sunroom
Google Home Max