Harmony Hub with the Deep Harmony Roon extension can do you what you want to a certain degree. You can configure it to use certain buttons to control the volume and input on DAC,amp, actives as long as they support ir. Play controls can control Roon directly . You can set a macro to control it all easily. What it won’t do is power off the nucleus but nothing other than the Webui can do that.
I use it in my dining room setup with some actives.