I use Audience ClairAudient ‘The ONE’ loudspeakers, supplemented with dual REL T/5i’s configured in stereo, to great effect.
I have the loudspeakers on wedge stands that point them directly at my ears. In fact, I added extra foam wedges, under the factory provided wedges, to get the optimal angle. See the Oct. '13 TAS review, by Steven Stone, for more details on the ideal desktop orientation for these particular speakers. If you have a deeper (front to back) desk than what I have, the extra wedges may not be necessary. In fact, if you have more desktop real estate available than I do, the previously mentioned IsoAcoustics stands might be perfect.
The Ones are very compact, so with my monitor raised to eye height, and despite the stacked wedges, the backs of the speakers are directly under the left and right sides of the monitor. Otherwise I’d be sitting too close to them due to the small desk (or, if I had the room on my desk, they would be further apart than is ideal for imaging).
This set up yields a fabulous sound stage. In fact, it’s (unexpectedly) close to being on par with my main system, just in a much smaller scale.
I like using single driver loudspeakers for near field set ups, as it avoids any possibility that I would be too close to multi-driver loudspeakers to allow the drivers to integrate and sound coherent. With the single driver, and no crossover, the coherence and transparency is superb.
The RELs are on the floor, to the left and right sides of my desk. The T/5is are sealed with down-firing 8" drivers, which are fast enough to keep up with The Ones, at least to my ears.
(I don’t have any association or relationship with Audience. I’m just a happy customer)