No, not really. I think the SE is newer and includes support for MQA.
One of the things you can do with Roon is to measure your room’s acoustics, and then add digital signal processing to Roon that will make it sound perfect given your speakers in your room. People do things like adding sound absorbers, curtains, covering tables (highly reflective surfaces), and all sorts of other steps to connect the speakers properly to the room.
I’m no expert here; @andybob has gathered together a number of threads on how to do digital room correction (using a calibrated microphone), but there are lots of physical steps you can take to remove sound reflections and/or absorption. A good starting article on this is How To Mitigate Problematic Room Acoustics. That will give you a basic understanding of the issues involved.