No, you cannot use USB to connect a Roon core or endpoint to a Denon AVR. People without experience in the AV realm need to stop recommending this AVR connection route. It happens too often, and it does not work.
AVRs – Denon included – have USB Type A connectors for iPods, USB drives, etc. Literally, almost zero AVRs have USB Type B connectors, which are required for USB connection to core or endpoint.
AVR connection options boil down to HDMI, coaxial, TOSLINK, or AirPlay (and Chromecast from some OEMs).
AJ