Thank you @connor.
It looks like the culprit may not be Zoom after all, but how my Mac/iPhone handles Bluetooth connected Apple AirPods. I noticed that when I was listening to a podcast and removed the pods from my ears, which normally pauses streaming media (YouTube etc.) Roon playback also paused.
This is odd as I only run Remote on the Mac. When I close Remote, the problem seems to go away.
This looks similar to Roon on macOS pauses network streamer when bluetooth headset is disconnected from the Mac
Noris mentioned in this thread “It’s possible that the headset itself sends a pause command to your Mac when powering off, and then the Mac forwards this to the currently active zone.” So it seems like we might be onto something. It just happened at approx 2pm PST on Feb. 2, and I can repro if you’d like me to. Cheers