Nucleus + USB Digital Out; MQA Capabilities

Roon will configure itself by default to a good setting. You only need to change the MQA setting if you want to override the default for some reason.

See the MQA Capabilities article here.. Let us know if you have a particular query after reading it.

Edit: The option selected in your screenshot is “No MQA Support”. This is referring to the Oppo, not the Nucleus. See this post by John of Roon Labs: