To be clear, your Roon Core is a Nucleus+ not an iMac?
Nonetheless, USB is a standard interface and both the iMac and Nucleus comply with this specification.
It would be helpful if you provided details of the DACs you are considering, so you are provided with appropriate support. For instance, do you want to control volume in Roon, is the DAC powered over USB, what audio equipment you are using etc.
The DAC I am considering is from Denafrips. There is no volume control and the DAC will be connected to an integrated amp via RCA. The signal path will be router to Nucleus+ via ethernet, Nucleus+ to DAC via USB and DAC to amp via RCA. The DAC will have another input from a CD Transport via Coax. If you need any additional information, please let me know.