Yes, but there is no official support and it’s very much in the realms of ‘tinkering’ — given the plethora of different VPN solutions there isn’t a single / simple guide to getting this working.
It will also depend on the speed and stability of your broadband network at both ends — it needs to be good to work reliably, what VPN solution you are currently using (or prepared to swap to) and how technically minded you are.
But depending on your current VPN solution, you may be able to use a UDP relay like udp-proxy-2020 to achieve what you want using. Other seem to also have had success with ZeroTier but I haven’t used it myself so can’t personally comment on how well it works.
Given you are currently evaluating Roon, why not give it a try and see if your network is stable enough to support a remote connection.
You’ve probably already come across these threads, but if not, these are likely the best place to start: