The best way to connect my new Nucleus

I bought a nucleus recently and I want to know what is the best way to connect this one to get a best sound possible. I have also a NDX 2 with Roon Ready. ( and sorry for my poor english )

I think to start I would connect the USB out from the Nucleus to the USB in on the NDX 2. That would be a very simple and clean connection. If it all works, you can then experiment with other options; ethernet, optical, etc.

Just connect it to the same network as your NDX 2.