DSPing is pretty specific to users systems and rooms.
Crossfeed on for headphone users being an exception. If you use heaphones turn it on, you may like it if you are primarily a speaker listener.
Upsampling might be another possibility but all DACs may or may not see an improvement from upsampling.
Here is a thread on upsampling:
Unless you have something specific to fix in your system, turn DSPing off completely would be my advise.