I know I can’t answer that definitively. I don’t work for Roon, and I’m not a ‘computer guy’.
I will say that is one of the largest libraries I’ve read about. Almost certainly in the top 1%, so based on what I know you are out on the edges what is known viz. library size and Roon performance.
There is this thread that discusses the challenges of these huge libraries. My takeaway was that it’s not an easy task to handle something that large. Doesn’t mean it can’t work, but all the little stuff seems to matter a lot.