This thread describe what I run to get Roon on Wine running. I’ve not experienced any blurring, but I’m running 1X scaling on 1080p. For an LTS, e.g., there’s no i386 architecture, so those steps can be removed.
What you may need to do, in addition, is use winecfg to adjust the scaling to match what you’ve done for Roon. You’ll need to increase the DPI.