HQP with Mytek Manhattan Network card

Yes. Ask if it can function as a NAA endpoint. The same as you would ask each manufacturer if it could be a Roon Endpoint.

Before you spend money, you should clearly define your target upsampling goals. The best DSD 512 filters take an enormous amount of horsepower and require additonal processing from a discrete Nvidia Cuda Graphics Card.

There are threads on here discussing just such processing needs. I would review these threads: