If your issue with Roon and wireguard has to do with the local endpoint disappearing and you are using Windows have a look at my post here. It may have to do with modern standby. I developed an easy workaround using autohotkey:
If your issue with Roon and wireguard has to do with the local endpoint disappearing and you are using Windows have a look at my post here. It may have to do with modern standby. I developed an easy workaround using autohotkey: