I’m not quite sure I get your question. It’s a bit apples and oranges.
I’m also looking into Control4 as I have a friend who is a home automation integrator.
It’s true that you can use Control4 as the software interface to control BluOS devices, or Roon Nucleus, but that’s what it is… a control interface. They do sell some hardware and amps of their own, but I’m not really sure the purpose of buying their rebranded stuff when you could buy true audio hardware (NAD, BluOS, Sonos, etc) and then have Control4 control it if you want.
The audio quality would almost certainly be better on any of the above. And you would have redundancy in how you control the audio… you could use for example, the BluOS app, the Control4 app, or Roon.
That’s the way I’m leaning… get Control4 to control the home… set inputs on the stereo etc… but once the stereo is on and set the way I want (using Control4’s home integration), then I’d likely switch apps and control the music with Roon.