My PC. A windows PC will not output to any connected USB speaker, or my Bluetooth heads. Roon tries to play but skips all music, all tracks. My headphones are connected [I can hear audio with other software]. The zones affected are those connected to my office PC. I have tried reinstalling Roon control software, restarting my PC etc. Nothing works. Yet the same outputs work on other software. And yes the outputs are setup.
I’ve activated diagnostics and it looks like the issue is happening with both your System Output and your WH-100XM5 zone as well on multiple sample rates, even standard 44.1/16, which is strange. Do you have Exclusive Mode turned on via your Windows PC menu? Is there any difference in behavior if you use Control + T to pause playback (this also force-releases the audio device).