I am having the same issue (trackpad clicks not registering sometimes). I am using a 2017 13-in MacBook Pro with the latest OS (Big Sur). I believe this is the same issue as the one described here. It seems that many of us are having this issue. I am currently trying out Roon and I would love to buy it if this issue is fixed. It is quite annoying/frustrating and really detracts from the otherwise great experience.