However, in this feature request thread, Danny referenced an older post of his, explaining that Roon cannot support screen readers because of how the application is designed. This older post was here:
However, a partial solution seems to be available by using the Roon Web Controller extension:
Of course, blind people may require different solutions such as screen readers, while users with very poor eyesight might find other solutions like strong magnification useful. Therefore, what’s possible may vary