You can either group zones to play the same music or you can start different music in different zones.
In principle, this is done in Roon‘s MUSE feature:
You can adjust manually with the parametric equalizer:
But for best results you measure the room with a microphone and create a convolution file, to correct the measured inadequacies. You need separate software for the measuring and filter creation. Then you load the filter into Roon:
If you have an iPhone or iPad, the easiest way for the measuring and filter creation is the HouseCurve app. It can even use the built-in microphone (though you can also attach a proper measuring microphone which you can get for about $100):
There is a discussion thread here on the forum:
Another option is the Focus Fidelity app which is also user friendly but more expensive:
(There is also the free REW app but it is quite complex)