It is possible it will be a while, if the application depends on 32bit code, it won’t be ported any time soon as Apple have ceased their support for 32bit code in newer MacOS Releases. Mono itself can be ported to native M1 and I have run various Mono tests, apart from Forms which requires 32 bit code.
Audio does seem a bit different though. My HDMI is showing up to 8 channels (7.1) of 16-24bit 48KHz Integer audio (in Audio/Midi Setup) or alternatively Encoded digital streams up to 768KHz. Which probably means that if it is correctly formatted, Roon could send any supported bitstream eg. DSD or DTS. Unfortunately 24bit 48Khz audio is all which is coming out at the moment, no matter the source. It still sounds fine, but it’d be nice if I can get the 192KHz Stereo I could get in Windows. Despite setting system audio to speakers instead of HDMI, I am still unable to get exclusive audio playing. HDMI 2 is capable of 1536KHz and up to 32 channels. I don’t know if any of us know fully what the M1 HDMI is capable of or how that is supposed to be harnessed under Big Sur